Evaluation of a porcine model to study in vivo platelet activation.
Identifieur interne : 002A36 ( Main/Exploration ); précédent : 002A35; suivant : 002A37Evaluation of a porcine model to study in vivo platelet activation.
Auteurs : RBID : pubmed:16143371English descriptors
- KwdEn :
- MESH :
- immunology : Blood Platelets, Decompression Sickness, Platelet Activation.
- pathology : Decompression Sickness.
- Animals, Cells, Cultured, Disease Models, Animal, Female, Male, Swine.
Abstract
In order to investigate if decompression sickness involves platelet activation an animal model was evaluated.
DOI: 10.1016/j.thromres.2005.08.003
PubMed: 16143371
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of a porcine model to study in vivo platelet activation.</title><author><name sortKey="S Fteland, Eirik" uniqKey="S Fteland E">Eirik Søfteland</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, University of Bergen, N-5021 Bergen, Norway. eirik.softeland@biomed.uib.no</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Biomedicine, University of Bergen, N-5021 Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Framstad, Tore" uniqKey="Framstad T">Tore Framstad</name></author><author><name sortKey="Nordvik, Astrid" uniqKey="Nordvik A">Astrid Nordvik</name></author><author><name sortKey="Bakken, Anne M" uniqKey="Bakken A">Anne M Bakken</name></author><author><name sortKey="Punwani, Chandru" uniqKey="Punwani C">Chandru Punwani</name></author><author><name sortKey="Morild, Inge" uniqKey="Morild I">Inge Morild</name></author><author><name sortKey="Hervig, Tor" uniqKey="Hervig T">Tor Hervig</name></author><author><name sortKey="Thorsen, Terje" uniqKey="Thorsen T">Terje Thorsen</name></author><author><name sortKey="Holmsen, Holm" uniqKey="Holmsen H">Holm Holmsen</name></author></titleStmt><publicationStmt><date when="2006">2006</date><idno type="doi">10.1016/j.thromres.2005.08.003</idno><idno type="RBID">pubmed:16143371</idno><idno type="pmid">16143371</idno><idno type="wicri:Area/Main/Corpus">002D96</idno><idno type="wicri:Area/Main/Curation">002D96</idno><idno type="wicri:Area/Main/Exploration">002A36</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blood Platelets (immunology)</term><term>Cells, Cultured</term><term>Decompression Sickness (immunology)</term><term>Decompression Sickness (pathology)</term><term>Disease Models, Animal</term><term>Female</term><term>Male</term><term>Platelet Activation (immunology)</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Blood Platelets</term><term>Decompression Sickness</term><term>Platelet Activation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Decompression Sickness</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Female</term><term>Male</term><term>Swine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to investigate if decompression sickness involves platelet activation an animal model was evaluated.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16143371</PMID><DateCreated><Year>2006</Year><Month>07</Month><Day>24</Day></DateCreated><DateCompleted><Year>2007</Year><Month>01</Month><Day>11</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0049-3848</ISSN><JournalIssue CitedMedium="Print"><Volume>118</Volume><Issue>3</Issue><PubDate><Year>2006</Year></PubDate></JournalIssue><Title>Thrombosis research</Title><ISOAbbreviation>Thromb. Res.</ISOAbbreviation></Journal><ArticleTitle>Evaluation of a porcine model to study in vivo platelet activation.</ArticleTitle><Pagination><MedlinePgn>341-52</MedlinePgn></Pagination><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">In order to investigate if decompression sickness involves platelet activation an animal model was evaluated.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Twenty-four thiopentone-midazolam-fentanyl-anaesthetized pigs in four groups received 5-min infusions of adenosine diphosphate (25 mg/kg) or platelet activating factor (0.4 microg/kg). Groups 1 and 2 (adenosine diphosphate, n=6 and platelet activating factor, n=6) were studied for 30 min and then sacrificed. Groups 3 and 4 (adenosine diphosphate, n=6 and platelet activating factor, n=6) were sacrificed immediately afterwards to study short-term changes. Haemodynamics, platelet counts and post mortem lung platelet aggregates were registered. Groups 1 and 2 also had indium platelet labelling, lung scintigraphy and platelet accumulation index calculations performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Adenosine diphosphate induced immediate and more profound transient shocks. Platelet and leukocyte count decreases and occurrences of post mortem lung platelet aggregates were significantly more profound in the 5-min adenosine diphosphate group (Group 3) than in the platelet activating factor group (Group 4). With platelet labelling there were positive platelet accumulation index trends in the 30-min adenosine diphosphate group (Group 1). Adenosine diphosphate also produced platelet aggregation in platelet-rich porcine plasma. Only adenosine diphosphate (an intermediate platelet agonist) showed signs of platelet activation when considering all platelet parameters. The model should be further evaluated with different bolus doses of adenosine diphosphate, but may be used to evaluate if gas bubbles introduced into the circulation (as with decompression sickness), or possibly if clinical drugs, might produce platelet activation in vivo.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Søfteland</LastName><ForeName>Eirik</ForeName><Initials>E</Initials><Affiliation>Department of Biomedicine, University of Bergen, N-5021 Bergen, Norway. eirik.softeland@biomed.uib.no</Affiliation></Author><Author ValidYN="Y"><LastName>Framstad</LastName><ForeName>Tore</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Nordvik</LastName><ForeName>Astrid</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bakken</LastName><ForeName>Anne M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Punwani</LastName><ForeName>Chandru</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Morild</LastName><ForeName>Inge</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Hervig</LastName><ForeName>Tor</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Thorsen</LastName><ForeName>Terje</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Holmsen</LastName><ForeName>Holm</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>09</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Thromb Res</MedlineTA><NlmUniqueID>0326377</NlmUniqueID><ISSNLinking>0049-3848</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Decompression Sickness</DescriptorName><QualifierName MajorTopicYN="Y">immunology</QualifierName><QualifierName MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Platelet Activation</DescriptorName><QualifierName MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Swine</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>6</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>8</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2005</Year><Month>9</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>9</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>1</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>9</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0049-3848(05)00352-X</ArticleId><ArticleId IdType="doi">10.1016/j.thromres.2005.08.003</ArticleId><ArticleId IdType="pubmed">16143371</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A36 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A36 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:16143371
|texte= Evaluation of a porcine model to study in vivo platelet activation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16143371" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |